The most frequent all-grade AEs of special interest (AESIs; ≥ 20%) were gastrointestinal events (n = 85; 73.9%), hypersensitivity (n = 56; 48.7%), pancreatic events (including enzyme elevations; n = 54; 47.0%), myelosuppression (including anemia, leukopenia, thrombocytopenia, and cytopenias affecting > 1 lineage; n = 42; 36.5%), hepatic events (including elevations of liver enzymes and/or bilirubin, and decreased albumin; n = 36; 31.3%), edema and fluid retention (n = 35; 30.4%), and hemorrhage (n = 27; 23.5%). This evidence concerns the gene ALB and anemia.