Furthermore, the antiproliferation of Sul-L1-RGD on two tumor cell lines, HT-29 and MDA-MB-231, was demonstrated under hypoxia conditions Therefore, as an efficient CAIX degrader, Sul-L1-RGD has great potential to be applied in cancer therapy with the ability to improve the hypoxic and acidic microenvironment of solid tumors. Here, CA9 is linked to neoplasm.