MED12L and amyotrophic lateral sclerosis: However, many H-MAGMA risk genes were not identified by MAGMA (AD Jansen, 62; AD Kunkle, 32; PD, 30; MS, 75; ALS 68 genes) (S3 Fig and S4 and S5 Tables), including the autophagy-related gene ATG16L1 at the INPP5D AD locus and purinergic receptor gene P2RY13 located at the PD MED12L locus (Fig 2c).