PINK1 and Parkinson disease: The H-MAGMA-risk genes NDUFAF2, BCKDK, and SUCNR1 have been associated with mitochondrial dysfunction, with BCKDK specifically linked to Parkinsonism and Maple Syrup Urine Disease (MSUD) [87,88], reinforcing evidence of mitochondrial impairment from early-onset PD mutations (PINK1, PARK7) and environmental factors [89,90].