H-MAGMA also identified genes located more distal from AD GWAS variants that were not found using standard mapping strategies, including endosome/endocytosis-associated genes (USP6NL, CNN2, RIN3, RAB8B), membrane-associated genes (SPPL2A, STX4, TRIP11), gene regulation (EED) and protein homeostasis (ATXN3). The gene discussed is SPPL2A; the disease is Alzheimer disease.