Either of these steps could be influenced by CPSF6–CA binding, since CA regulates both reverse transcription and post-reverse transcription steps (45, 46, 83, 84, 118, –, 121) and the CPSF6–CA interaction affects nuclear entry and post-entry steps of HIV-1 infection (109, 115, 122). The gene discussed is CPSF6; the disease is HIV-1 infection.