Our bioinformatics and computational analyses demonstrated that lurasidone may regulate the serotonergic synapse signaling pathway by targeting proteins such as MAOB, HTR1A, HTR2A, HTR3A, SLC18A2, HTR1B, and HTR7 to induce treatment‐emergent mania in people with bipolar depression. The gene discussed is HTR1A; the disease is bipolar disorder.