Our bioinformatics and computational analyses demonstrated that lurasidone may regulate the serotonergic synapse signaling pathway by targeting proteins such as MAOB, HTR1A, HTR2A, HTR3A, SLC18A2, HTR1B, and HTR7 to induce treatment‐emergent mania in people with bipolar depression. This evidence concerns the gene SLC18A2 and bipolar disorder.