Conversely, the knockdown of these genes partially mitigated the pro-proliferative and pro-migratory effects induced by hyperglycemia in BC cells.<h4>Conclusion</h4>Our findings suggested that CCNB2, XRCC2, and CENPI may serve as key pathogenic mediators linking T2DM and BC. Here, CCNB2 is linked to Hyperglycemia.