A co‐IP assay with transient infection of N. benthamiana leaves (35S:Myc‐MdZFP3/35S:FLAG‐MdTPL4/35S:MdEAEL1 or 35S:Myc‐MdZFP3/35S:FLAG‐MdTPL4) demonstrated that MdEAEL1 inhibited the interaction between MdZFP3 and MdTPL4, and this inhibitory effect could be reversed by treatment with MG132 (Figure9A), indicating that MdEAEL1 mediates the ubiquitination and degradation of MdZFP3, weakening the interaction between MdZFP3 and MdTPL4. The gene discussed is MYC; the disease is infection.