NFKBIA and atherosclerosis: As we know, the transcriptional factor NF‐κB governs inflammatory gene expression and plays a pivotal role in atherosclerosis.[22] In the activation of NF‐κB signaling cascade, the upstream IKKβ kinase was phosphorylated and then phosphorylated IκBα to promote IκBα degradation, which then released the NF‐κB p65 subunit.