IL1B and infection: While infection with A. baumannii increased the expression of inflammasome-related genes, such as Nlrp3 (about 1.1) and Il1β (about 0.8) in the lungs of previously healthy mice, the transcript levels of these genes were lower in the two-hit mice (about 0.7 for Nlrp3 gene and about 0.6 for Il1β) (Figure 3A).