The upregulation of TMEM163, STX4, RAB7L1, and ITGAM (positive PWAS z score) and the downregulation of TMEM175, DOC2A, CTSB, ASPHD1, CD38, DGKQ, AKR1C1, and PARK2 (negative PWAS z score) were associated with increased PD risk. The gene discussed is STX4; the disease is Parkinson disease.