These CAR-TMYXV cells induce not only apoptosis and pyroptosis but also ATP1A1-dependent autosis through a synergy of T cell-derived IFNG/IFNγ and AKT1 signaling with the MYXV M-T5 protein-triggered SKP1 (S-phase kinase associated protein 1) and PIK3C3 signaling, significantly assisting tumor eradication. The gene discussed is SKP1; the disease is neoplasm.