Further mediation analysis showed that DunedinPoAm mediated 9.0% (95%CI 0.1-43.2%) of the association between B2M and cognitive performance.<h4>Conclusion</h4>These findings suggested a substantial link between elevated B2M levels and cognitive decline among U.S. older adults, partly mediated through the faster pace of aging. The gene discussed is B2M; the disease is Mental deterioration.