A novel fusion gene <i>NRF1::PDGFRA</i> was identified in a patient with myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions (MLN-TK), harboring the chromosome abnormality t(4;7)(q12;q32). The gene discussed is PDGFRA; the disease is Increased total eosinophil count.