Subsequently, recombinant Asian elephant IFNα and IFNβ proteins were expressed and assessed for bioactivity <i>in-vitro</i>, relative to recombinant human IFNs, using a novel infection model incorporating primary Asian elephant fibroblasts and bovine alphaherpesvirus 1 (BoHV-1) as a surrogate for EEHV. Here, IFNB1 is linked to infection.