,99 Simultaneously, CREB/cAMP signaling, the signaling pathway most enriched in classical NEC in this cell-type segment concordant analysis (e.g., CREB5, Figure S21B), stimulates intracellular calcium flux in neutrophils to promote degranulation and increased bactericidal activity in the intestinal lumen. The gene discussed is CREB1; the disease is necrotizing enterocolitis.