NOX1 and necrotizing enterocolitis: As components of the pathogen-induced cytokine storm signaling pathway, genes associated with redox-mediated regulation of microbial growth and host defense and innate immune activation and trafficking were upregulated substantially in the classical NEC epithelium (CCL20, CCL28, LCN2, and NOX1 [NADPH oxidase 1]; Figure S21C) and immune (CCR1, CX3CR1, and CXCL6) compartments, respectively.