Since the binding of transferrin receptor (TFR) to transferrin is the principal route for cells to uptake iron (Fe3+), the regulation of transferrin receptor activity may have an impact on the process of ferroptosis.[3a] In breast cancer, Mediator of Cell Motility 1 (MEMO1) is capable of binding to transferrin receptor (TFR) and being involved in the regulation of ferroptosis.[38] Additionally, a study has indicated that Cu+ could bind to MEMO1.[39] We hypothesize that Cu+ may influence the level of TFR through binding to MEMO1 to affect ferroptosis. The gene discussed is TFRC; the disease is breast cancer.