CP and cancer: Ceruloplasmin is indispensable in the iron cycle, and its deficiency is likely to influence the cellular uptake and export of iron, thereby disrupting the ferroptosis.[7, 24, 34] However, in the realm of cancer biology, the prevailing perspective holds that ceruloplasmin plays a certain role in suppressing ferroptosis via facilitating the oxidation of intracellular free Fe2+ and enhancing iron export, yet it remains unclear whether its promotion of iron transport and absorption would further promote ferroptosis.