Some oxidative enzymes, such as NADPH oxidase (NOX), lipoxygenase (LOX), and cytochrome P450 oxidoreductase (POR), play a crucial role in the production of ROS.[3b,c] For the synthesis of biological membranes and signaling molecules, the fatty acid metabolism of cancer cells undergoes numerous alterations.[17] Against this backdrop, adequate fatty acid supply becomes another decisive contributor to lipid peroxidation. The gene discussed is POR; the disease is cancer.