The iron bound to ferritin can be reclaimed to the labile iron pool through the ferritinophagy mostly mediated by the cargo protein Nuclear Receptor Coactivator 4 (NCOA4), which facilitates ferroptosis and has demonstrated potential clinical application value in cancer treatment.[48] Since the NCOA4 bound to ferritin ultimately be delivered to the autophagosome by binding to autophagy‐related (ATG) proteins such as Microtubule Associated Protein 1 Light Chain 3 (MAP1LC3), factors influencing the autophagy process will impact ferritinophagy. The gene discussed is NCOA4; the disease is cancer.