GPNMB and neurodegenerative disease: Based on reports that GPNMB can exert an anti-inflammatory effect by promoting inflammation resolution and our observations that increased GPNMB expression is associated with reduced cytokine release and MHC-II expression with knock-down ameliorating both, we propose an alternative strategy: that lysosomal function in FTD and other neurodegenerative diseases where it is impaired may be rectified by GPNMB therapy.