Regarding lysotracker MFI, despite no significant differences being observed in control ASO conditions between FTD-GRN patient monocytes and those from NHCs, a significant decrease in Lysotracker MFI was observed in FTD-GRN classical monocytes relative to NHCs upon the knock down of GPNMB via ASOs in vehicle conditions (Fig. 1G, H). The gene discussed is GPNMB; the disease is frontotemporal dementia.