For several cancer subtypes, pyroptosis promotes tumor growth and metastasis through inflammatory cytokine release [91–93], activation of oncogenic signaling pathways (e.g., STAT3, PI3K) [94, 95], and dysregulation of gasdermin proteins (e.g., GSDMB, GSDMC) [56, 96]. The gene discussed is GSDMB; the disease is cancer.