Of the 5 patients who did not respond to treatment with cabergoline, 3 patients remained hypogonadal: a 69-year-old man who complained of erectile dysfunction but ruled out other hypogonadism-related problems (fatigue, depression, etc.)and refused testosterone treatment, a 51-year-old man whose testosterone increased from 1.7 ng/ml to 2.5 ng/ml and his sexual dysfunction improved despite above-normal prolactin levels, and a 57 year-old patient that received testosterone replacement. This evidence concerns the gene PRL and depressive symptom measurement.