While macroadenomas tend to extend beyond the sella turcica and cause a variety of symptoms resulting from the pressure exerted on adjacent tissues (e.g., visual field defect, hypopituitarism), microprolactinomas are small and rarely protrude outside the pituitary gland and thus their effect is usually limited to increased prolactin secretion [4, 5]. This evidence concerns the gene PRL and Microprolactinoma.