Gene set enrichment analysis indicated that Nrf2-bound genes associated with neuroprotective pathways, such as axon development and neuron development (with significant overlap with genes involved in synaptic plasticity), as well as autophagy (proteolysis involved in protein catabolic process) genes that were significantly downregulated in AD hippocampi compared to controls (Fig. 2A–C) and (Table S1). Here, NFE2L2 is linked to Alzheimer disease.