NFE2L2 and Alzheimer disease: A similar reduction in Nrf2+ astrocytes was observed in the 3 ​× ​Tg-AD mouse model at 10 months of age, where the percentage of Nrf2+ astrocytes dropped from 79 ​% in wild-type mice to 41 ​% in 3 ​× ​Tg-AD mice.