ARLN and type 2 diabetes mellitus: Of note, human genetic association studies (genomewide association study [GWAS]) from the Type 2 Diabetes Knowledge Portal (http://type2diabetesgenetics.org/) found modest yet significant associations between C4ORF3 and BMI (p = 4.54e−8), LDL cholesterol (p = 2.14e−9), and coronary artery disease (p = 2.80e−10).