In Parkinson’s disease mouse models, both gene expression and protein levels of ALKBH5 and IGF2BP2 in the substantia nigra were upregulated,49 which in consistent with the trend of ALKBH5 upregulation observed in aging cochleae, suggesting that ALKBH5 may play a significant role in geriatric disease. Here, ALKBH5 is linked to Parkinson disease.