Further investigation has revealed that COPS5 interacts with and stabilizes mitogen‐activated protein kinase 2 (MK2) through deubiquitination, promoting the phosphorylation of heat shock protein beta‐1 (HSPB1), which is critical for ferroptosis suppression, rendering HCC cells resistant to sorafenib treatment. Here, HSPB1 is linked to hepatocellular carcinoma.