Similarly, curcumin, a natural dietary supplement, works as an anticancer agent, as suggested by numerous preclinical studies across cancer types,[65] and as a COPS5 inhibitor, as supported by multiple studies.[15, 34] It has advanced into clinical trials for the treatment of colon cancer (NCT01490996), breast cancer (NCT01740323, NCT03072992), cervical cancer (NCT06080841), and pancreatic cancer (NCT00094445, NCT00192842), where it has been used either alone or in combination with chemotherapy and exhibits safe and tolerable antitumor activities. This evidence concerns the gene COPS5 and colonic neoplasm.