COPS5 and hepatocellular carcinoma: To confirm the results of our screening, we knocked out COPS5 using the CRISPR/Cas9 technique in the human HCC cell lines HepG2 and SK‐Hep1 as well as in the murine HCC cell line H22 (Figure2A; Figure S3A, Supporting Information) and subsequently examined their response to sorafenib.