The expression data for COPS5, ZRANB2, TSPAN17, HAUS1, KDELR3, and CDK5R1 from 67 patients with HCC who received sorafenib were obtained from GSE109211(https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE109211).[13] RNA‐seq data from the TCGA–LIHC dataset were downloaded from TCGA database (https://portal.gdc.cancer.gov). The gene discussed is COPS5; the disease is hepatocellular carcinoma.