An examination of the clinical relevance of these genes in human HCC using the The Cancer Genome Atlas (TCGA) liver hepatocellular carcinoma (LIHC) dataset revealed significant upregulation of 15 genes in HCC samples compared with normal liver tissues, of which COPS5, ZRANB2, TSPAN17, HAUS1, KDELR3, and CDK5R1 levels demonstrated a notable positive correlation with worse overall survival (OS) in patients with HCC (Figure 1E,F; Figure S1A,B, Supporting Information). The gene discussed is COPS5; the disease is hepatocellular carcinoma.