Additionally, a stronger effect on sorafenib sensitivity in cells was observed upon KD of COPS5 than upon KD of MT1G, which has previously been shown to trigger sorafenib resistance in HCC (Figure S3D–G, Supporting Information).[18] Taken together, these results indicate that ablation of COPS5 suppresses HCC cell growth and sensitizes HCC cells to sorafenib treatment. Here, MT1G is linked to hepatocellular carcinoma.