To explore whether the pharmacological inhibition of COPS5 enhances the therapeutic efficacy of sorafenib against HCC, we used curcumin, a small‐molecule compound that has been demonstrated to inhibit not only COPS5‐associated deubiquitinase activity but also COPS5 expression,[15, 34] for in vitro and in vivo studies. This evidence concerns the gene COPS5 and hepatocellular carcinoma.