Indeed, in mice bearing colon adenocarcinoma 26 (C26) tumors, the complement pathway was identified as the most enriched pathway from genes upregulated in the muscles of both moderately and severely cachectic mice (63), with C3 protein levels found to also be increased in the muscle of cachectic C26 mice and in mice undergoing cachexia in response to FOLFIRI chemotherapy treatment (64). Here, C3 is linked to colon adenocarcinoma.