PDGFRA and neoplasm: In this model, KPC cells isolated from the tumor of a KPC mouse are injected into the mouse pancreas, which induces key features of PDAC-associated cachexia including myofiber atrophy and weakness (31), and pathological remodeling in the diaphragm consistent with that of PDAC patients, including infiltration of leukocytes, expansion of platelet-derived growth factor receptor α–positive (PDGFRα+) mesenchymal progenitors, and collagen deposition (32).