In this regard, increasing levels of complement component C4A mRNA in both muscle and adipose tissue were found to correlate with increased cancer weight loss grade in PDAC patients (61), while C3a, a cleavage product of C3, was recently shown to be significantly higher in plasma from cachectic pancreatic cancer patients with inflammation compared with those without cachexia (62). The gene discussed is C3; the disease is familial pancreatic carcinoma.