Notably, CD84 OE+shCD84 mice carried THP1 cells that at relapse not only lost CD84 silencing, but maintained statistically significant CD84 upregulation compared with the mock/shCtrl engrafted mice (P = 0.045) (Figure 2J and Supplemental Figure 3H), further supporting that CD84 overexpression facilitates AML progression, this effect being specifically mitigated by CD84 deletion. Here, CD84 is linked to acute myeloid leukemia.