Moreover, it has been found that CD84 is an essential survival factor for CLL, acting by activating a signaling cascade that involves CD84 tyrosine phosphorylation, EAT-2 recruitment, and increased AKT phosphorylation, resulting in BCL2 upregulation (21); importantly, this survival cascade also plays a pivotal role in AML pathophysiology (22). Here, CD84 is linked to B-cell chronic lymphocytic leukemia.