CD84 and acute myeloid leukemia: With the intent to generate stable AML clones that maintained CD84 downregulation, our data show that, when CD84 was completely downmodulated using a double shCD84 targeting, mouse leukemia cells lost their clonogenic capabilities, resulting in a complete absence of colonies, further supporting that CD84 upregulation is essential for the leukemogenesis process and its role is conserved through the species.