HSPA5 and autosomal dominant medullary cystic kidney disease with or without hyperuricemia: In line with previous studies (48, 51–53), the ADTKD-causing mutant was localized intracellularly (Figure 3D) and triggered ER stress (GRP78 and XBP1s) and ER stress–induced cell death (CHOP and TRIB3) gene expression (Figure 3E).