In addition, we found that Ang II treatment resulted in markedly increased HINT1 in mouse aortic smooth muscle cells (MASMCs), human aortic smooth muscle cells (HASMCs), and rat aortic smooth muscle cells (RASMCs) (Figure 1, G and H), while it did not affect HINT1 expression in mouse aortic endothelial cells (Supplemental Figure 1, B and C) and mouse bone marrow–derived macrophages (Supplemental Figure 1, D and E), implying an important role of HINT1 in VSMCs in aortic aneurysm. Here, AGT is linked to aortic aneurysm.