CXCL13 and pneumonitis: When the corresponding values from patients with or without pneumonitis were applied to the model with this predictive equation, patient groups with the irAE pneumonitis and the non-irAE group could be statistically distinguished as distinct components (sensitivity; 75%, specificity; 92%, Adonis test P < 0.01) (Figure 7E), suggesting the predictive value of combined evaluation of CXCL13 and ICOS for the development of the irAE pneumonitis.