Moreover, the levels of CXCL13, a B cell–attracting chemokine, tended to be increased in plasma of patients with pneumonitis but not in that from patients without any irAEs (Supplemental Figure 9F and Supplemental Table 2) (22), and the inflammatory cytokine IL-6 has been reportedly involved in anti–PD-(L)1 therapy–induced pneumonitis (35). This evidence concerns the gene CD274 and pneumonitis.