Previous studies have reported that hypoxic conditions can induce a series of cellular stress responses in cancers and autoimmune diseases.[15, 16] SIRT1, a significant deacetylase, plays a vital role in processes such as cell stress response, metabolism, and aging.[17] Our experimental results demonstrated that, under hypoxic conditions, the expression level of SIRT1 was substantially altered and influenced the autophagy process of the HK2 cell line by FoxO1 and FoxO3 (Figures 1 and 2). The gene discussed is FOXO1; the disease is cancer.