In addition, QYD treatment inhibited the phosphorylation of PI3K and AKT in M5-stimulated HaCaT cells and upregulated p-FOXO1 protein expression level.<h4>Conclusion</h4>QYD can inhibit the excessive proliferation and inflammatory response of keratinocytes by regulating the PI3K/AKT/FoxO pathway, suggesting that QYD may be an attractive prescription for psoriasis. This evidence concerns the gene FOXO1 and psoriasis.