SPRR3 and rheumatoid arthritis: SPRC has demonstrated therapeutic potential in various conditions, including cardiovascular diseases (Ping et al. 2023; Tran et al. 2019), neurodegenerative disorders (Xi et al. 2023; Gong et al. 2011), and inflammatory diseases (Sidhapuriwala et al. 2012; Peng et al. 2021; Ma et al. 2022), such as Rheumatoid arthritis (RA).