TNFSF10 and colorectal carcinoma: Although the number of apoptotic organoid cells was similaramong unconjugated, sc-TRAIL, and Ori-6S treatments at 24 h (Figures S6 and S7), Ori-6S induced earlier apoptosisin both PDAC and CRC organoids compared to sc-TRAIL and unconjugatedcontrols, likely due to enhanced clustering of death receptors.