VEGFA and wet macular degeneration: Our findings predict rs943080 to play a pathogenic role in the RPE by affecting expression of VEGFA, the primary therapeutic target for wet AMD.54 Agreeing with this, prior bulk RNA-seq of human induced pluripotent stem cell-derived RPE showed significantly lower VEGFA levels in cells from a donor homozygous for the rs943080 risk allele than from heterozygous controls.55