When fused with another gene (FLI1, ATF1, CREM, RBFOX2, ERG, TCF7L2, TFEB and ZNF384), they form abnormal chimeric transcription factors (e.g., EWSR1-FLI1, EWSR1-ATF1 and TAF15-ZNF384) that drive the pathogenesis of a variety of soft tissue tumors, leukemias and mesotheliomas55, 91, 92. The gene discussed is CREM; the disease is soft tissue neoplasm.