HLA-C and neoplasm: Therefore, the formation of disjoint sub-micron clusters in the resting state aids clear discrimination between target tumor cells expressing high and low NKG2DL concentrations even when the concentration of HLA-C varies in the infected/tumor target cells, whereas the homogeneously distributed NKRs can reliably distinguish between high and low NKG2DL signals only for bimodal distribution of HLA-C concentrations.