To further characterize peripheral and central immune dysregulation associated with LRRK2 mutations and PD, we determined levels of 65 cytokines, chemokines, growth factor targets, and soluble receptors/ligands, which have reported roles in regulating immune and inflammatory responses in serum and CSF samples from participants enrolled in the LRRK2 Cohort Consortium (LCC). This evidence concerns the gene LRRK2 and Parkinson disease.