In terms of the CSF: serum ratios of the analytes, the LRRK2+/PD group had significantly decreased concentration ratios of TNF-RII (p=0.008), SDF-1 alpha (p=0.013), and IL-16 (p=0.042) compared to LRRK2-/PD. This evidence concerns the gene LRRK2 and Parkinson disease.