NEU1 and neoplasm: CRISPR/Cas9, CCK-8 assay, transwell assays, oil red O staining, RNA-sequencing, immunofluorescence and co-immunoprecipitation (Co-IP) and <i>in vivo</i> experiments were used to investigate the biological function of NEU1 and the therapeutic effect of OP in liver cancer.<h4>Results</h4>We demonstrated that NEU1 expression was significantly elevated in liver cancer cells and tumor tissues.