However, brain Aβ and microgliosis were positively correlated (<i>p</i> < 0.05) with serum alanine aminotransferase, a marker of liver injury, in Tg2576 mice.<h4>Conclusion</h4>Chronic alcohol intake, resulting in mild liver injury, caused modest but significant AD-relevant changes in aged Tg2576 mice, which correlated with liver injury; the latter suggests significant liver-brain crosstalk in an AD model of moderate alcohol intake. The gene discussed is GPT; the disease is Alzheimer disease.