The administration of Gö 6983 or the overexpression of IRS-1 effectively inhibited the activation of the PKC/IRS-1/ERK signaling pathway, leading to reduced proliferation and migration of PASMCs compared to stimulation with PDGF-BB alone (<i>p</i> < 0.05).<h4>Conclusions</h4>The PKC/IRS-1/ERK signaling pathway is implicated in the abnormal proliferation and migration of PASMCs, contributing to pulmonary vascular remodeling in PAH. Here, IRS1 is linked to pulmonary arterial hypertension.