Thus, there is a need for more comprehensive research to verify the tasks and clinical significance of IL-33 and ST2 in HNSCC.<h4>Objectives</h4>The objective of this study was to evaluate the potential of differentially expressed IL-33 and ST2 in tumor tissues that could serve as novel biomarkers in HNSCC.<h4>Material & methods</h4>The Web of Science, Scopus, and PubMed electronic databases were searched and analyzed from January 2013 to July 2023.<h4>Results</h4>Nine studies fulfilling the inclusion criteria were analyzed. The gene discussed is IL33; the disease is neoplasm.