Additionally, elevated serum levels of AST, urea, and D-dimer, as well as increased plasma concentrations of IL-10, IFN-γ, and TNF-α, have been associated with co-infections involving Mtb and SARS-CoV-2.<h4>Conclusion</h4>These biomarkers may reflect the complex interplay between the two pathogens and their impact on host immune responses and disease progression. The gene discussed is TNF; the disease is coinfection.