Thus, this study aimed to investigate the potential impact of GR activation on the hepatic Th2 immune response in schistosomiasis using the synthetic glucocorticoid dexamethasone.<h4>Method</h4><i>In vivo</i>, <i>Schistosoma japonicum</i>-infected mice were treated with dexamethasone, while in vitro studies were conducted on Th2 cells. The gene discussed is NR3C1; the disease is schistosomiasis.