LRP5 and type 2 diabetes mellitus: Purpose This study was designed to explore the association of sclerostin (<i>SOST</i>) and low-density lipoprotein receptor-related protein-5 (<i>LRP5</i>) gene polymorphisms with early-onset T2DM in the young population of Uttarakhand, which is novel given that no studies have focused on this link within an Indian demographic.