However, we did find clonal memory of AP-1 with this approach that, as we saw with in vivo stem cell memory, includes both a mean shift in AP-1 activity (P=0.019) and a subpopulation of colitis-derived clones that demonstrate exceptionally high AP-1 motif accessibility (12.2% vs 2.7%; Fig. 2i). Here, JUN is linked to colitis.