CD226 and systemic lupus erythematosus: In CD and SLE, a~1.6 million base pair genomic region on q14.11 of chromosome 13 demonstrated an rg,local of 1.70 (P = 0.028), a region harboring a common risk variant in the ELF1 gene (rs7329174).39,40 An additional positive rg,local of 1.37 (P = 0.012) was observed on p11.31-p11.23 of chromosome 18, each harboring a different variant in the CD226 gene.