In both CD-SLE and UC-SLE analyses, a ~ 0.68 million base pair genomic region on chromosome 9 at p24.2-p24.1 with a positive rg,local of 1.01 (P = 0.004; CD-SLE) and rg,local of 1.02 (P = 0.002; UC-SLE) was observed; disease harbors > 1 risk variants in the JAK2 gene. Here, JAK2 is linked to systemic lupus erythematosus.