TP53 and cancer: Specifically, BRCA1 had 3.6% (209/5807) pathogenic variants, 203 of which were linked to cancer pathogenesis; TP53 had 15.9% (214/1348) with 212 variants associated with cancer; and PTEN had 21.75% (223/1025), with 148 associated with cancer (Supplementary Table 9).