Our aim was to determine which blood pressure metrics (e.g., systolic bloodpressure, diastolic blood pressure, pulse pressure) most robustly relate to fluid biomarkersof brain aging in a cohort of functionally intact older adults, including astrocyticactivation (GFAP), neuronal axon breakdown (NfL), and AD pathobiology (pTau181;Aβ42/40). Here, NEFL is linked to Alzheimer disease.