All animals had signs of immunosuppression including depleted peripheral CD4 counts (<500 cells/μL of blood) in 4/7 (57%) of animals (median 494 (274–1090) cells/μL of blood) and a blood CD4/CD8 ratio of <1, a biomarker of HIV/AIDS disease progression, in 7/7 (100%) of animals (Supplemental Figure 3, Supplemental Table 1)19. The gene discussed is CD4; the disease is AIDS.