Obese mice that do not express leptin present an increase in periprostatic WAT, atrophy of the acini with epithelial changes indicative of prostatic intraepithelial neoplasia (PIN), an increase in markers of cell death (Caspase‐3) and inflammation (Interleukin‐6 and Tumor Necrosis Factor‐alpha). Here, LEP is linked to prostate intraepithelial neoplasia.