Overnutrition triggers insulin resistance and uncontrolled inflammatory responses in WAT, leading to chronic low‐grade inflammation with increased inflammatory cell infiltration and secretion of pro‐inflammatory cytokines (tumor necrosis factor alpha, TNF‐α; monocyte chemoattractant protein1, MCP‐1; interleukin‐6, IL‐6; and interleukin‐8, IL‐8) [18, 19] (Figure 1B). Here, TNF is linked to Insulin resistance.