In the context of reproduction and male reproductive health, leptin, adiponectin, resistin, visfatin, apelin, chemerin, omentin‐1, vaspin, and asprosin are adipokines that are intimately involved with the regulation of spermatogenesis and steroidogenesis, and in the state of weight gain and obesity, they deserve great attention. The gene discussed is SERPINA12; the disease is obesity due to melanocortin 4 receptor deficiency.