In this review, we address in an updated way the structural and functional characteristics of WAT as well as the link between obesity and changes in the signaling pathways of the adipokines leptin, adiponectin, resistin, visfatin, apelin, chemerin, omentin‐1, vaspin, and asprosin in male reproduction. The gene discussed is APLN; the disease is obesity due to melanocortin 4 receptor deficiency.