Occurrence of vascular lesions and cardiac injury, including ventricular hypertrophy, ventricular wall thickening, increased coronary artery inflammation, interstitial coronary fibrosis, microthrombi and intracardiac platelet/fibrin aggregates (Francis et al., 2021; Rizvi et al., 2022; Xue et al., 2022). Observations of elevated levels of serum cardiac troponin I, cholesterol, HDL, LDL, VLDL and long-chain fatty acid triglycerides (Rizvi et al., 2022). The gene discussed is TNNI3; the disease is cardiac hypertrophy.